A major breakthrough in Parkinson's Disease (PD) research has led to the discovery of a new biomarker called alpha-synuclein. This protein can detect PD in patients and those at risk. A renowned PD foundation and other organizations conducted a significant longitudinal study, marking a milestone in PD treatment. Alpha-synuclein is crucial in the aggregation of neuronal proteins, a key feature of PD, and is induced in gut cells by specific gut microbes like Desulfovibrio bacteria. Worms fed Desulfovibrio bacteria from PD patients developed larger alpha-synuclein aggregates than those fed bacteria from healthy individuals. Spinal fluid from over a thousand people was tested for alpha-synuclein aggregates found in Lewy bodies. A top US university developed a non-invasive technique to test the alteration of the LRRK2 protein, linked to PD, and its downstream pathways using brain cell proteins in urine samples. An AI-based tool can predict PD onset with 96% accuracy up to 15 years before clinical diagnosis, based on blood sample analysis. Research has also shown lower levels of a certain metabolite in people at risk of PD. PD symptoms vary among patients, and disease progression can be categorized into five stages, ranging from mild to severe impairment requiring a wheelchair.
Following are some of the interesting articles:
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New breakthrough in Parkinson’s Research – A new biomarker
A new biomarker for Parkinson’s Disease has been discovered recently. The protein target (alpha-synuclein) can be helpful in detecting PD in patients as well as in those who are not yet diagnosed with PD but are at risk. The world-famous foundation of Parkinson’s Disease along with several other organizations, conducted this longitudinal study. This marks a major breakthrough from Parkinson’s Disease treatment standpoint.
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Role of bacteria in aggregation of rogue protein
One of the key features of Parkinson’s Disease is the aggregation of neuronal protein (α-synuclein). This protein is induced in gut cells by specific gut microbes such as Desulfovibrio bacteria. During statistical analysis, it has been found that worms which were fed on Desulfovibrio bacteria from PD patients harbored large α-synuclein aggregates as compared to those who were fed on Desulfovibrio bacteria from healthy people.
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α-synuclein seed amplification assay
Spinal fluid of over thousand people was tested to aggregates of α-synuclein. α-synuclein is found in Lewy bodies. The study of α-synuclein seed amplification assay is a game changer for diagnosis, research and trials. Any tests may be conducted only after consulting your doctor as per doctor’s advice.
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Non-invasive testing of Parkinson’s Disease using liquid biopsy
A top university in the US has developed a technique that can enable the scientists to test if LRRK2 protein (which is linked to PD) and the downstream pathways are altered in the samples from PD patients. This could lead to a non-invasive technique for testing. The technique identifies protein from brain cells in urine samples.
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Artificial Intelligence for predicting PD before it happens!
Researchers have developed a Artificial Intelligence based tool that can predict the onset of Parkinson’s Disease with 96% accuracy upto 15 years before a clinical diagnosis. This prediction os made purely on the basis of analysis of blood sample. Research has also linked the various percentage of certain metabolite in healthy vs unhealthy people. Lower level of a certain metabolite is found in case of people with risk of Parkinson’s Disease.
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Tips of those newly diagnosed with Parkinson’s Disease
Overview, patients may experience tremors, stiffness, slowness, gait changes, constipation, low blood pressure on standing and speech distortion. Every patient may experience the disease differently. Based on the level of symptoms, the disease progression can be divided into 5 stages from mildest to becoming wheelchair bound.
Following are the details of the tips:
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